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Axayacatl was the Aztec ruler of the city of Tenochtitlan who conquered Tlatelolco, Tenochtitlan's sister city. Using the insulting behavior of a few Tlatelolcan citizens, he invaded his neighbor, killed its ruler and replaced him with a military governor. The Tlatelolcan city council lost any voice it had in forming Aztec policy.

He took power in 1469; his reign was preceded by Moctezuma I and followed by his brother Tízoc.