Ciprofloxacin is a synthetic antibiotic. This is a generic and
international name for the compound that can have numerous brand names, including Cipro.
This antibiotic belongs to a wider group called fluoroquinolones.
Ciprofloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase. This enzyme is crucial for spatial conformation of DNA molecules. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than mammalian one.
Ciprofloxacin is a wide spectrum antibiotic that is active against both
Gramm-positive and Gramm-negative bacteria.
- Hemophilus influenzae
- Neisseria gonorrhoeae
- Neisseria menigitidis
- Moraxella catarrhalis
- Helicobacter pylori
- Mycobacterium intracellulare
- Legionella sp.
- Pseudomonas aeruginosa
- Bacillus anthracis - that causes anthrax
Weak activity against :
No activity against:
The drug is available for oral and parenteral use. It is used in lower respiratory infections (pneumonias), urinary tract infections, STDs, septicemias, Legionellosis and atypical Mycobacterioses.
It is contraindicated in children, pregnancy, epilepsia.
Ciprofloxacin can cause photosensitivity reactions and can elevate plasma theophylline levels to toxic values.
Dosage in respiratory infections 500-1500 mg a day in 2 doses.