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A powerful noble family in medieval and renaissance Rome, supplying one pope and many other leaders, and fighting with their rivals the Orsini family for influence. Only one Colonna ever became pope, Pope Martin V, who ended the Great Schism.

According to their family tradition, the Colonna are a branch of the counts of Tusculum. The first cardinal from the family was appointed in 1192 when Giovanni Colonna was made Cardinal-Priest of Saint Prisca.

Vittoria Colonna, friend of Michelangelo