John Cade

HomePage | Recent changes | View source | Discuss this page | Page history | Log in |

Printable version | Disclaimers | Privacy policy

Dr John Frederick Joseph Cade, Australian psychiatrist and discoverer (in 1948) of the effects of Lithium carbonate as a mood stabilizer in the treatment of Bipolar Disorder.

He was originally investigating the hypothesis that mania was related to urea, and using lithium citrate as part of an animal experiment. However, his use of careful controls in his experiments revealed that the lithium salt had a calming effect by itself. A small-scale trial on humans revealed that lithium had a powerful effect on mania in people.

However, the toxicity of lithium prevented its use in psychiatry for some years.


  • Cade, JFJ; Lithium salts in the treatment of psychotic excitement. Med J Aust 1949, 36, p349-352