May 16 is the 136th day of the year in the Gregorian calendar (137th in leap years). There are 229 days remaining.
- 1718: Maria Gaetana Agnesi (Italian mathematician)
- 1905: Henry Fonda (actor)
- 1912: Studs Terkel (writer)
- 1919: Liberace (Wladziu Valentino)]] (concert pianist)
- 1953: Pierce Brosnan (actor)
- 1955: Debra Winger (actress)
- 1966: Janet Jackson (singer)
- 1970: Gabriela Sabatini (tennis player)
- 1990: Jim Henson, creator of the Muppets.