The p53 gene is a gene that codes for a protein for tumor suppression. It is very important for cells in multicellular organisms to suppress uncontrolled cell division. More than 50% of tumors in humans show a mutation or deletion of the p53 gene.
The p53 protein consists of three units (or domains):
- A domain that activates transcription factors.
- A domain that recognizes specific DNA sequences.
- A domain that recognized damaged DNA, such as misaligned base pairs or single-stranded DNA.
The p53 protein can regulate the cell in several ways: