Quinine is a natural alkaloid having antipyretic, antimalarial and analgesic properties. It is especially used in the prevention of malaria along with quinacrine, chloroquine, and primaquine. It was derived from the bark of the Cinchona, a Peruvian tree. Quinine was isolated in 1820 and synthesis was achieved in 1944.
Excessive use of quinine may cause cinchonism and even death.